association between the a1298c polymorphism of the methylenetetrahydrofolate reductase gene and recurrent spontaneous abortion

نویسندگان

amin khaleghparast m.sc. of biology - genetics, science and research branch of islamic azad university, tehran, iran

sharif khaleghparast b. eng. of industrial engineering, iran university of science and technology (iust), tehran, iran

hossein khaleghparast ph.d. in public law, science and research branch of islamic azad university, tehran, iran

چکیده

introduction: a factor known to cause thrombophilia in women with recurrent pregnancy loss (rpl) is the a1298c polymorphism of methylenetetrahydrofolate reductase gene (mthfr). this study aimed to determine the association between rpl and this polymorphism in iranian patients. methods: in this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortions and 10 women with at least two live births without a miscarriage, who  referred to baqiyatallah hospital and avicenna infertility clinic, were analyzed for mthfr a1298c polymorphism using pcr-rflp method. the results obtained via estimating the genotype of each polymorphism were analyzed using spss v16.   results: thirteen subjects (43.3 %) with rpl and 6 women (20 %) in the control group were heterozygous for mthfr a1298c polymorphism. c allele frequency in the patient group was higher than the control group (41.7% and 40% for the patient and control groups, respectively). conclusion: the prevalence of mthfr a1298c polymorphism was slightly higher in rpl patients compared to the controls. this finding failed to support the relationship between this polymorphism and the increasing risk of rpl in the evaluated iranian women.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion

Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

متن کامل

Evaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion

Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...

متن کامل

evaluation of the association between the c677t polymorphism of methylenetetrahydrofolate reductase gene and recurrent spontaneous abortion

introduction: one factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (rsa) is c677t polymorphism of methylenetetrahydrofolate reductase gene. this study aimed to determine the association between rsa and mthfr c677t polymorphism in iranian patients. methods: in this case-control study, 30 patients with previous history of two or more consecutive unexpla...

متن کامل

C677T and A1298C Mutations in the Methylenetetrahydrofolate Reductase Gene in Patients with Recurrent Abortion from the Iranian Azeri Turkish

Background To assess whether the C677T and A1298C mutations in the methylenetetrahydrofolate reductase (MTHER) gene are associated with recurrent abortion (RA), we determined the frequencies of the T677 and C1298 mutations in patients and controls. MaterialsAndMethods Mutations were determined by a RFLP-PCR method in 53 patients and 61 matched controls. Results The frequencies of T alleles were...

متن کامل

Association between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion

Introduction: Recurrent spontaneous abortion is defined as the occurrence of more than two clinical miscarriages in one woman. Several factors, including endocrine irregularities, genetics and environmental factors, are involved in this kind of infertility.The aim of this study was to survey the association of HOXA10 (rs267601473) polymorphism with the risk of recurrent spontaneous abortion in ...

متن کامل

Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis.

Several independent studies have reported the role of the methylenetetrahydrofolate reductase gene (MTHFR) A1298C polymorphism in strokes, but the results are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed in the present study. In this meta-analysis, a total of 13 studies, including 1974 cases and 2660 controls, were selected to evaluate the...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of neonatology

جلد ۵، شماره ۲، صفحات ۷-۱۱

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023